Kang Mi-Rae had a timid personality due to her ugly appearance. She was teased by people and even bullied when she attended school. Now, Kang Mi-Rae is beautiful after undergoing plastic surgery, but she still has her timid personality. Kang Mi-Rae starts her first year at a university. People are still mean to her and call her “Gangnam Beauty” in a derogatory manner. Meanwhile, Do Kyung-Seok attends the same university. He does not judge people by their appearance. He cares about what’s on the inside rather than outside. Do Kyung-Seok begins to like Kang Mi-Rae.
A man does not have much time to live. Giving everything he has, he struggles to help a woman whose life was destroyed because of him. Soo-Ho (Kim Jung-Hyun) is the CEO of a restaurant and the son of a family that runs large company W. Due to him, Ji-Hyun’s (Seohyun) life is ruined. Soo-Ho wants to turn back time for Ji-Hyun. Meanwhile, Ji-Hyun had a bright personality and easily socialized with others, but things changed. Her younger sibling suddenly dies and her time stops right there.
A romance takes place between a neurosurgeon and an endocrinologist. The neurosurgeon is Han Seung-Joo (Ji Hyun-Woo). He has a strong desire for winning. The endocrinology doctor is Joo In-A (Lee Si-Young). She is obsessed about hormones.
Gong Woo-Jin (Yang Se-Jong) is a 30-year-old single man and he works as a set designer. Due to a trauma he experienced 13 years ago, he does not want to have a relationship with others. When Woo Seo-Ri (Shin Hye-Sun) was 17, she fell into a coma. 13 years later, she wakes up from her coma. Her mental age is still that of a 17-year-old, but she is now 30-years-old. Gong Woo-Jin and Woo Seo-Ri get involved with each other and fall in love.